Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Poorly differentiated and anaplastic thyroid carcinomas are very aggressive, almost invariably lethal neoplasms for which no effective treatment exists. These tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited. We have undertaken a det...

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Detalles Bibliográficos
Autores principales: Champa, Devora, Orlacchio, Arturo, Patel, Bindi, Ranieri, Michela, Shemetov, Anton A, Verkhusha, Vladislav V, Cuervo, Ana Maria, Di Cristofano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085168/
https://www.ncbi.nlm.nih.gov/pubmed/27144341
http://dx.doi.org/10.18632/oncotarget.9121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085168/
https://www.ncbi.nlm.nih.gov/pubmed/27144341
http://dx.doi.org/10.18632/oncotarget.9121

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