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Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis
Poorly differentiated and anaplastic thyroid carcinomas are very aggressive, almost invariably lethal neoplasms for which no effective treatment exists. These tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited. We have undertaken a det...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085168/ https://www.ncbi.nlm.nih.gov/pubmed/27144341 http://dx.doi.org/10.18632/oncotarget.9121 |