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Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling

Synonymous mutations, which do not alter the encoded amino acid, have been routinely assumed to be ‘neutral’ and would have no effect on phenotype or fitness. Yet increasing observations have emerged to overturn this conventional concept. However, convicted elucidation of how synonymous mutations ex...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Chen, Yuan, Qi, Hong, Liu, Liyu, Shuai, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085179/
https://www.ncbi.nlm.nih.gov/pubmed/27129147
http://dx.doi.org/10.18632/oncotarget.8963