Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

Radiotherapy (RT) remains a standard therapeutic modality for breast cancer patients. However, intrinsic or acquired resistance limits the efficacy of RT. Here, we demonstrate that CHK1 inhibitor AZD7762 alone significantly inhibited the growth of radioresistant breast cancer cells (RBCC). Given the...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Lai, Jinzhi, Du, Zhanwen, Gao, Jinnan, Yang, Shuming, Gorityala, Shashank, Xiong, Xiahui, Deng, Ou, Ma, Zhefu, Yan, Chunhong, Susana, Gonzalo, Xu, Yan, Zhang, Junran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085184/
https://www.ncbi.nlm.nih.gov/pubmed/27167194
http://dx.doi.org/10.18632/oncotarget.9156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085184/
https://www.ncbi.nlm.nih.gov/pubmed/27167194
http://dx.doi.org/10.18632/oncotarget.9156

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