Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Mutations in isocitrate dehydrogenase 1 (IDH1) are characteristic of low-grade gliomas. We recently showed that mutant IDH1 cells reprogram cellular metabolism by down-regulating pyruvate dehydrogenase (PDH) activity. Reduced pyruvate metabolism via PDH could lead to increased pyruvate conversion to...

Descripción completa

Detalles Bibliográficos
Autores principales: Viswanath, Pavithra, Najac, Chloe, Izquierdo, Jose L., Pankov, Aleksandr, Hong, Chibo, Eriksson, Pia, Costello, Joseph F., Pieper, Russell O., Ronen, Sabrina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085201/
https://www.ncbi.nlm.nih.gov/pubmed/27144334
http://dx.doi.org/10.18632/oncotarget.9006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085201/
https://www.ncbi.nlm.nih.gov/pubmed/27144334
http://dx.doi.org/10.18632/oncotarget.9006

Ejemplares similares