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Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Mutations in isocitrate dehydrogenase 1 (IDH1) are characteristic of low-grade gliomas. We recently showed that mutant IDH1 cells reprogram cellular metabolism by down-regulating pyruvate dehydrogenase (PDH) activity. Reduced pyruvate metabolism via PDH could lead to increased pyruvate conversion to...

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Detalles Bibliográficos
Autores principales:	Viswanath, Pavithra, Najac, Chloe, Izquierdo, Jose L., Pankov, Aleksandr, Hong, Chibo, Eriksson, Pia, Costello, Joseph F., Pieper, Russell O., Ronen, Sabrina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085201/ https://www.ncbi.nlm.nih.gov/pubmed/27144334 http://dx.doi.org/10.18632/oncotarget.9006

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