CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model

We evaluated the role of the CXCL12/CXCR4 (C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4) axis in aggrecanase-mediated cartilage degradation, and explored the underlying mechanism in a post-traumatic osteoarthritis rat model. Expression of CXCL12/CXCR4 and ADAMTS-5 was analyzed in...

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Detalles Bibliográficos
Autores principales: Lu, Weiwei, Shi, Jia, Zhang, Jinming, Lv, Zhengtao, Guo, Fengjing, Huang, Hui, Zhu, Wentao, Chen, Anmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085615/
https://www.ncbi.nlm.nih.gov/pubmed/27690009
http://dx.doi.org/10.3390/ijms17101522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085615/
https://www.ncbi.nlm.nih.gov/pubmed/27690009
http://dx.doi.org/10.3390/ijms17101522

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