Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect

Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization. Abnormality of repolarization increases risk of...

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Detalles Bibliográficos
Autores principales: Yan, Meng, Fan, Pan, Shi, Yanhui, Feng, Lifang, Wang, Junnan, Zhan, Ge, Li, Baoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085681/
https://www.ncbi.nlm.nih.gov/pubmed/27690007
http://dx.doi.org/10.3390/ijms17101648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085681/
https://www.ncbi.nlm.nih.gov/pubmed/27690007
http://dx.doi.org/10.3390/ijms17101648

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