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Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and confo...

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Detalles Bibliográficos
Autores principales: Singh, Warispreet, Fields, Gregg B., Christov, Christo Z., Karabencheva-Christova, Tatyana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085758/
https://www.ncbi.nlm.nih.gov/pubmed/27754420
http://dx.doi.org/10.3390/ijms17101727