Cargando…
Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1
Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and confo...
Autores principales: | Singh, Warispreet, Fields, Gregg B., Christov, Christo Z., Karabencheva-Christova, Tatyana G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085758/ https://www.ncbi.nlm.nih.gov/pubmed/27754420 http://dx.doi.org/10.3390/ijms17101727 |
Ejemplares similares
-
Conformational Dynamics, Ligand Binding and Effects of Mutations in NirE an S-Adenosyl-L-Methionine Dependent Methyltransferase
por: Singh, Warispreet, et al.
Publicado: (2016) -
Structural Insights from Molecular Dynamics Simulations
of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase
por: Ainsley, Jon, et al.
Publicado: (2018) -
Mechanistic Insights into the Reaction of Chlorination of Tryptophan Catalyzed by Tryptophan 7-Halogenase
por: Karabencheva-Christova, Tatyana G., et al.
Publicado: (2017) -
Conformational Effects on the Circular Dichroism of Human Carbonic Anhydrase II: A Multilevel Computational Study
por: Karabencheva-Christova, Tatyana G., et al.
Publicado: (2013) -
Catalysis by the
Non-Heme Iron(II) Histone Demethylase
PHF8 Involves Iron Center Rearrangement and Conformational Modulation
of Substrate Orientation
por: Chaturvedi, Shobhit S., et al.
Publicado: (2019)