Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central role in many physiological and pathological processes. Although several MMP inhibitors have been synthesized over the years, none reached the market because of off-target effects, due to the presence o...

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Detalles Bibliográficos
Autores principales: Ammazzalorso, Alessandra, De Filippis, Barbara, Campestre, Cristina, Laghezza, Antonio, Marrone, Alessandro, Amoroso, Rosa, Tortorella, Paolo, Agamennone, Mariangela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085792/
https://www.ncbi.nlm.nih.gov/pubmed/27782083
http://dx.doi.org/10.3390/ijms17101768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085792/
https://www.ncbi.nlm.nih.gov/pubmed/27782083
http://dx.doi.org/10.3390/ijms17101768

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