The study of brain functional connectivity in Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086060/ https://www.ncbi.nlm.nih.gov/pubmed/27800157 http://dx.doi.org/10.1186/s40035-016-0066-0 |
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author | Gao, Lin-lin Wu, Tao |
author_facet | Gao, Lin-lin Wu, Tao |
author_sort | Gao, Lin-lin |
collection | PubMed |
description | Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD. This review aims to provide an overview of current research involving functional network disruption in PD relating to motor and non-motor symptoms. Investigations into functional network connectivity will further our understanding of the mechanisms underlying the effectiveness of clinical interventions, such as levodopa and deep brain stimulation treatment. In addition, identification of PD-specific neural network patterns has the potential to aid in the development of a definitive diagnosis of PD. |
format | Online Article Text |
id | pubmed-5086060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50860602016-10-31 The study of brain functional connectivity in Parkinson’s disease Gao, Lin-lin Wu, Tao Transl Neurodegener Review Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD. This review aims to provide an overview of current research involving functional network disruption in PD relating to motor and non-motor symptoms. Investigations into functional network connectivity will further our understanding of the mechanisms underlying the effectiveness of clinical interventions, such as levodopa and deep brain stimulation treatment. In addition, identification of PD-specific neural network patterns has the potential to aid in the development of a definitive diagnosis of PD. BioMed Central 2016-10-28 /pmc/articles/PMC5086060/ /pubmed/27800157 http://dx.doi.org/10.1186/s40035-016-0066-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Gao, Lin-lin Wu, Tao The study of brain functional connectivity in Parkinson’s disease |
title | The study of brain functional connectivity in Parkinson’s disease |
title_full | The study of brain functional connectivity in Parkinson’s disease |
title_fullStr | The study of brain functional connectivity in Parkinson’s disease |
title_full_unstemmed | The study of brain functional connectivity in Parkinson’s disease |
title_short | The study of brain functional connectivity in Parkinson’s disease |
title_sort | study of brain functional connectivity in parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086060/ https://www.ncbi.nlm.nih.gov/pubmed/27800157 http://dx.doi.org/10.1186/s40035-016-0066-0 |
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