The study of brain functional connectivity in Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap...

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Autores principales: Gao, Lin-lin, Wu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086060/
https://www.ncbi.nlm.nih.gov/pubmed/27800157
http://dx.doi.org/10.1186/s40035-016-0066-0
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author Gao, Lin-lin
Wu, Tao
author_facet Gao, Lin-lin
Wu, Tao
author_sort Gao, Lin-lin
collection PubMed
description Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD. This review aims to provide an overview of current research involving functional network disruption in PD relating to motor and non-motor symptoms. Investigations into functional network connectivity will further our understanding of the mechanisms underlying the effectiveness of clinical interventions, such as levodopa and deep brain stimulation treatment. In addition, identification of PD-specific neural network patterns has the potential to aid in the development of a definitive diagnosis of PD.
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spelling pubmed-50860602016-10-31 The study of brain functional connectivity in Parkinson’s disease Gao, Lin-lin Wu, Tao Transl Neurodegener Review Parkinson’s disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD. This review aims to provide an overview of current research involving functional network disruption in PD relating to motor and non-motor symptoms. Investigations into functional network connectivity will further our understanding of the mechanisms underlying the effectiveness of clinical interventions, such as levodopa and deep brain stimulation treatment. In addition, identification of PD-specific neural network patterns has the potential to aid in the development of a definitive diagnosis of PD. BioMed Central 2016-10-28 /pmc/articles/PMC5086060/ /pubmed/27800157 http://dx.doi.org/10.1186/s40035-016-0066-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Gao, Lin-lin
Wu, Tao
The study of brain functional connectivity in Parkinson’s disease
title The study of brain functional connectivity in Parkinson’s disease
title_full The study of brain functional connectivity in Parkinson’s disease
title_fullStr The study of brain functional connectivity in Parkinson’s disease
title_full_unstemmed The study of brain functional connectivity in Parkinson’s disease
title_short The study of brain functional connectivity in Parkinson’s disease
title_sort study of brain functional connectivity in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086060/
https://www.ncbi.nlm.nih.gov/pubmed/27800157
http://dx.doi.org/10.1186/s40035-016-0066-0
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