Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model

PURPOSE: The proliferation of gene-panel testing precipitates the need for a breast cancer (BC) risk model that incorporates the effects of mutations in several genes and family history (FH). We extended the BOADICEA model to incorporate the effects of truncating variants in PALB2, CHEK2 and ATM. ME...

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Detalles Bibliográficos
Autores principales: Lee, Andrew J., Cunningham, Alex P., Tischkowitz, Marc, Simard, Jacques, Pharoah, Paul D., Easton, Douglas F., Antoniou, Antonis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086091/
https://www.ncbi.nlm.nih.gov/pubmed/27464310
http://dx.doi.org/10.1038/gim.2016.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086091/
https://www.ncbi.nlm.nih.gov/pubmed/27464310
http://dx.doi.org/10.1038/gim.2016.31

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