Cargando…

PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/hTERT Pathway in Lung Adenocarcinoma A549 Cells

PTEN plays an essential role in tumorigenesis and both its mutation and inactivation can influence proliferation, apoptosis, and cell cycle progression in tumor cells. However, the precise role of PTEN in lung cancer cells has not been well studied. To address this, we have generated lung adenocarci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xiao-Xiao, Cao, Lan-Yu, Chen, Xi, Xiao, Jian, Zou, Yong, Chen, Qiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086351/ https://www.ncbi.nlm.nih.gov/pubmed/27822469 http://dx.doi.org/10.1155/2016/2476842

Ejemplares similares

NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer
por: Feng, Xu, et al.
Publicado: (2017)

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar Fibroblasts
por: Zhu, Hua-Yu, et al.
Publicado: (2014)

PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells
por: Shin, Jin Woo, et al.
Publicado: (2021)

Downregulation of hTERT contributes to ovarian cancer apoptosis and inhibits proliferation of ovarian cancer cells
por: Wang, Qing-An-Zi, et al.
Publicado: (2020)

KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth
por: Hu, Wenxian, et al.
Publicado: (2016)

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells
por: Ries, Alexander, et al.
Publicado: (2023)

HKR3 regulates cell cycle through the inhibition of hTERT in hepatocellular carcinoma cell lines
por: Choi, Sung Hoon, et al.
Publicado: (2020)

Antiproliferative Effects of Ferulic, Coumaric, and Caffeic Acids in HepG2 Cells by hTERT Downregulation
por: Afshari, Afsoon, et al.
Publicado: (2022)

Inhibition of hTERT/telomerase contributes to the antitumor activity of pristimerin in pancreatic ductal adenocarcinoma cells
por: DEEB, DORRAH, et al.
Publicado: (2015)

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway
por: Zhang, Changlin, et al.
Publicado: (2017)

Expression of (NES-)hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress
por: Kovalenko, Olga A., et al.
Publicado: (2010)

The intrabody targeting of hTERT attenuates the immortality of cancer cells
por: Zhu, Xiangying, et al.
Publicado: (2009)

Exploring hTERT promoter methylation in cutaneous T‐cell lymphomas
por: Chebly, Alain, et al.
Publicado: (2021)

Spotlight on hTERT Complex Regulation in Cutaneous T-Cell Lymphomas
por: Ropio, Joana, et al.
Publicado: (2023)

Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors
por: Bartsch, Sophie, et al.
Publicado: (2021)

hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines
por: Nguyen, Eric, et al.
Publicado: (2022)

Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter
por: Miao, Beiping, et al.
Publicado: (2021)

siRNA suppression of hTERT using activatable cell-penetrating peptides in hepatoma cells
por: Li, Hua, et al.
Publicado: (2015)

Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells
por: Moirangthem, Dinesh Singh, et al.
Publicado: (2014)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

Tetrazolium Violet Induced Apoptosis and Cell Cycle Arrest in Human Lung Cancer A549 Cells
por: Zhang, Xiao-Hong, et al.
Publicado: (2012)

PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenocarcinoma cells
por: de Souza, Ludmilla Regina, et al.
Publicado: (2014)

Proteome alteration induced by hTERT transfection of human fibroblast cells
por: Mazzucchelli, Gabriel D, et al.
Publicado: (2008)

Functional and gene expression analysis of hTERT overexpressed endothelial cells
por: Takano, Haruna, et al.
Publicado: (2008)

hTERT promotes cell adhesion and migration independent of telomerase activity
por: Liu, Haiying, et al.
Publicado: (2016)

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
por: Suso, Else M. Inderberg, et al.
Publicado: (2011)

Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
por: Inderberg-Suso, Else-Marit, et al.
Publicado: (2012)

hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells
por: Romaniuk-Drapała, Aleksandra, et al.
Publicado: (2021)

A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression
por: Malhotra, Sanandan, et al.
Publicado: (2017)

Regulation of hTERT by BCR-ABL at multiple levels in K562 cells
por: Chai, Juin Hsien, et al.
Publicado: (2011)

hTERT promoter activity identifies osteosarcoma cells with increased EMT characteristics
por: YU, LING, et al.
Publicado: (2014)

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity
por: Yu, Ling, et al.
Publicado: (2013)

Knockdown of hTERT and Treatment with BIBR1532 Inhibit Cell Proliferation and Invasion in Endometrial Cancer Cells
por: Kong, Weimin, et al.
Publicado: (2015)

Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells
por: Yu, Hyeran, et al.
Publicado: (2020)

Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway
por: Chen, Wei-Sheng, et al.
Publicado: (2011)

Silencing of the hTERT Gene by shRNA Inhibits Colon Cancer SW480 Cell Growth In Vitro and In Vivo
por: Liu, Ai-Qun, et al.
Publicado: (2014)

Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway
por: Ko, Eul-Bee, et al.
Publicado: (2022)

hTERT promoter methylation promotes small cell lung cancer progression and radiotherapy resistance
por: Zhai, Guangsheng, et al.
Publicado: (2020)

Downregulation of hTERT: An Important As(2)O(3) Induced Mechanism of Apoptosis in Myelodysplastic Syndrome
por: Xu, Weilai, et al.
Publicado: (2014)

MST4 inhibits human hepatocellular carcinoma cell proliferation and induces cell cycle arrest via suppression of PI3K/AKT pathway
por: Hao, Wei-Chao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4tra6vmc5eb3dbnmpo72n3oclo