E1A enhances cellular sensitivity to DNA-damage-induced apoptosis through PIDD-dependent caspase-2 activation

Expression of the adenoviral protein, E1A, sensitizes mammalian cells to a wide variety of apoptosis-inducing agents through multiple cellular pathways. For example, E1A sensitizes cells to apoptosis induced by TNF-superfamily members by inhibiting NF-kappa B (NF-κB)-dependent gene expression. In co...

Descripción completa

Detalles Bibliográficos
Autores principales: Radke, Jay R, Siddiqui, Zeba K, Figueroa, Iris, Cook, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086486/
https://www.ncbi.nlm.nih.gov/pubmed/27833761
http://dx.doi.org/10.1038/cddiscovery.2016.76

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086486/
https://www.ncbi.nlm.nih.gov/pubmed/27833761
http://dx.doi.org/10.1038/cddiscovery.2016.76

Ejemplares similares