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E1A enhances cellular sensitivity to DNA-damage-induced apoptosis through PIDD-dependent caspase-2 activation

Expression of the adenoviral protein, E1A, sensitizes mammalian cells to a wide variety of apoptosis-inducing agents through multiple cellular pathways. For example, E1A sensitizes cells to apoptosis induced by TNF-superfamily members by inhibiting NF-kappa B (NF-κB)-dependent gene expression. In co...

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Detalles Bibliográficos
Autores principales:	Radke, Jay R, Siddiqui, Zeba K, Figueroa, Iris, Cook, James L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086486/ https://www.ncbi.nlm.nih.gov/pubmed/27833761 http://dx.doi.org/10.1038/cddiscovery.2016.76

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