Cargando…

Structural Maturation of HIV-1 Reverse Transcriptase—A Metamorphic Solution to Genomic Instability

Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT)—a critical enzyme of the viral life cycle—undergoes a complex maturation process, required so that a pair of p66 precursor proteins can develop conformationally along different pathways, one evolving to form active polymerase and ribo...

Descripción completa

Detalles Bibliográficos
Autor principal:	London, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086598/ https://www.ncbi.nlm.nih.gov/pubmed/27690082 http://dx.doi.org/10.3390/v8100260

Ejemplares similares

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
por: Kirby, Thomas W., et al.
Publicado: (2023)

Asymmetric conformational maturation of HIV-1 reverse transcriptase
por: Zheng, Xunhai, et al.
Publicado: (2015)

Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution
por: Ilina, Tatiana V., et al.
Publicado: (2020)

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase
por: Singh, Kamalendra, et al.
Publicado: (2010)

Effect of Lysyl–tRNA Synthetase on the Maturation of HIV-1 Reverse Transcriptase
por: Ilina, Tatiana V., et al.
Publicado: (2020)

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
por: Warren, Kylie, et al.
Publicado: (2009)

Reverse Transcriptase Activity in Mature Spermatozoa of Mouse
por: Giordano, Roberto, et al.
Publicado: (2000)

Approved HIV reverse transcriptase inhibitors in the past decade
por: Li, Guangdi, et al.
Publicado: (2022)

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
por: Rhee, Soo-Yon, et al.
Publicado: (2016)

Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
por: Famiglini, Valeria, et al.
Publicado: (2016)

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
por: Ilina, Tatiana, et al.
Publicado: (2012)

Metamorphic proteins: the Janus proteins of structural biology
por: Madhurima, Kulkarni, et al.
Publicado: (2021)

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
por: Singh, Kamal, et al.
Publicado: (2019)

Unfolding the HIV-1 reverse transcriptase RNase H domain – how to lose a molecular tug-of-war
por: Zheng, Xunhai, et al.
Publicado: (2016)

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance
por: Acosta-Hoyos, Antonio J., et al.
Publicado: (2010)

Docking study of HIV-1 reverse transcriptase with phytochemicals
por: Seal, Abhik, et al.
Publicado: (2011)

Architecture of an HIV-1 reverse transcriptase initiation complex
por: Larsen, Kevin P., et al.
Publicado: (2018)

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
por: Bauman, Joseph D., et al.
Publicado: (2008)

Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase
por: Nakamura, Akiyoshi, et al.
Publicado: (2015)

NMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
por: Thammaporn, Ratsupa, et al.
Publicado: (2015)

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
por: Singh, Kamalendra, et al.
Publicado: (2014)

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases
por: Álvarez, Mar, et al.
Publicado: (2017)

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
por: Singh, Abhimanyu K., et al.
Publicado: (2022)

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
por: Zheng, Xunhai, et al.
Publicado: (2014)

HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data
por: Tarasova, Olga, et al.
Publicado: (2018)

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
por: Schauer, Grant, et al.
Publicado: (2013)

The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors
por: Sluis-Cremer, Nicolas
Publicado: (2014)

Molecular Docking Studies of HIV-1 Resistance to Reverse Transcriptase Inhibitors: Mini-Review
por: Tarasova, Olga, et al.
Publicado: (2018)

Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
por: Masso, Majid, et al.
Publicado: (2013)

Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase
por: Wöhrl, Birgitta M.
Publicado: (2019)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2008)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2009)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
por: Masuda, Takao, et al.
Publicado: (2022)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
por: Mirambeau, Gilles, et al.
Publicado: (2007)

The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance
por: Garforth, Scott J., et al.
Publicado: (2014)

Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: from treatment to prevention
por: Gupta, Ravindra K, et al.
Publicado: (2013)

HIV-1 Subtype B Protease and Reverse Transcriptase Amino Acid Covariation
por: Rhee, Soo-Yon, et al.
Publicado: (2007)

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
por: Smith, Steven J., et al.
Publicado: (2014)

HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies
por: Mahboubi-Rabbani, Mohammad, et al.
Publicado: (2021)

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
por: Meleddu, Rita, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rhu2j0m2h7b7pvqdp4mg5omsgv