Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations. To aid in designing effective NNRTIs against the resistant mutants, it...

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Detalles Bibliográficos
Autores principales: Lai, Ming-Tain, Munshi, Vandna, Lu, Meiqing, Feng, MeiZhen, Hrin-Solt, Renee, McKenna, Philip M., Hazuda, Daria J., Miller, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086599/
https://www.ncbi.nlm.nih.gov/pubmed/27669286
http://dx.doi.org/10.3390/v8100263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086599/
https://www.ncbi.nlm.nih.gov/pubmed/27669286
http://dx.doi.org/10.3390/v8100263

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