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Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues. Hereby, we describe several isoforms and a cDNA clone sequence, corresponding to PII SVMP ho...

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Detalles Bibliográficos
Autores principales: Camacho, Erika, Sanz, Libia, Escalante, Teresa, Pérez, Alicia, Villalta, Fabián, Lomonte, Bruno, Neves-Ferreira, Ana Gisele C., Feoli, Andrés, Calvete, Juan J., Gutiérrez, José María, Rucavado, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086652/
https://www.ncbi.nlm.nih.gov/pubmed/27754342
http://dx.doi.org/10.3390/toxins8100292