Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

Two new scalarane sesterterpenoids, 12β-(3′β-hydroxybutanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (1) and 12β-(3′β-hydroxypentanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (2), along with one known tetraprenyltoluquinol-related metabolite (3), were isolated from the sponge Carteriospo...

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Detalles Bibliográficos
Autores principales: Lai, Kuei-Hung, Liu, Yi-Chang, Su, Jui-Hsin, El-Shazly, Mohamed, Wu, Chih-Fung, Du, Ying-Chi, Hsu, Yu-Ming, Yang, Juan-Cheng, Weng, Ming-Kai, Chou, Chia-Hua, Chen, Guan-Yu, Chen, Yu-Cheng, Lu, Mei-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086919/
https://www.ncbi.nlm.nih.gov/pubmed/27796344
http://dx.doi.org/10.1038/srep36170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086919/
https://www.ncbi.nlm.nih.gov/pubmed/27796344
http://dx.doi.org/10.1038/srep36170

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