DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis

Skeletal muscle wasting in facioscapulohumeral muscular dystrophy (FSHD) results in substantial morbidity. On a disease-permissive chromosome 4qA haplotype, genomic and/or epigenetic changes at the D4Z4 macrosatellite repeat allows transcription of the DUX4 retrogene. Analysing transgenic mice carry...

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Detalles Bibliográficos
Autores principales: Knopp, Paul, Krom, Yvonne D., Banerji, Christopher R. S., Panamarova, Maryna, Moyle, Louise A., den Hamer, Bianca, van der Maarel, Silvère M., Zammit, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087662/
https://www.ncbi.nlm.nih.gov/pubmed/27744317
http://dx.doi.org/10.1242/jcs.180372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087662/
https://www.ncbi.nlm.nih.gov/pubmed/27744317
http://dx.doi.org/10.1242/jcs.180372

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