Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca(2+) release and Ca(2+) influx

Transient receptor potential (TRP) mucolipins (TRPMLs), encoded by the MCOLN genes, are patho-physiologically relevant endo-lysosomal ion channels crucial for membrane trafficking. Several lines of evidence suggest that TRPMLs mediate localised Ca(2+) release but their role in Ca(2+) signalling is n...

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Detalles Bibliográficos
Autores principales: Kilpatrick, Bethan S., Yates, Elizabeth, Grimm, Christian, Schapira, Anthony H., Patel, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087663/
https://www.ncbi.nlm.nih.gov/pubmed/27577094
http://dx.doi.org/10.1242/jcs.190322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087663/
https://www.ncbi.nlm.nih.gov/pubmed/27577094
http://dx.doi.org/10.1242/jcs.190322

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