Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

DNA polymerase theta (Polθ) is a specialized A-family DNA polymerase that functions in processes such as translesion synthesis (TLS), DNA double-strand break repair and DNA replication timing. Overexpression of POLQ, the gene encoding Polθ, is a prognostic marker for an adverse outcome in a wide ran...

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Detalles Bibliográficos
Autores principales: de Rugy, T. Goullet, Bashkurov, M., Datti, A., Betous, R., Guitton-Sert, L., Cazaux, C., Durocher, D., Hoffmann, J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087683/
https://www.ncbi.nlm.nih.gov/pubmed/27612511
http://dx.doi.org/10.1242/bio.018028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087683/
https://www.ncbi.nlm.nih.gov/pubmed/27612511
http://dx.doi.org/10.1242/bio.018028

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