Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis

Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulat...

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Detalles Bibliográficos
Autores principales: Hansen, Sarah A., Hart, Marcia L., Busi, Susheel, Parker, Taybor, Goerndt, Angela, Jones, Kevin, Amos-Landgraf, James M., Bryda, Elizabeth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087826/
https://www.ncbi.nlm.nih.gov/pubmed/27528400
http://dx.doi.org/10.1242/dmm.025767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087826/
https://www.ncbi.nlm.nih.gov/pubmed/27528400
http://dx.doi.org/10.1242/dmm.025767

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