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Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis
Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087826/ https://www.ncbi.nlm.nih.gov/pubmed/27528400 http://dx.doi.org/10.1242/dmm.025767 |