Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake

KEY POINTS: Acute biliary pancreatitis is a sudden and severe condition initiated by bile reflux into the pancreas. Bile acids are known to induce Ca(2+) signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on stellate cells are unexplored. Here we show that cholate...

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Detalles Bibliográficos
Autores principales: Ferdek, Pawel E., Jakubowska, Monika A., Gerasimenko, Julia V., Gerasimenko, Oleg V., Petersen, Ole H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Molecular and cellular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088250/
https://www.ncbi.nlm.nih.gov/pubmed/27406326
http://dx.doi.org/10.1113/JP272774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088250/
https://www.ncbi.nlm.nih.gov/pubmed/27406326
http://dx.doi.org/10.1113/JP272774

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