The Effect of Geometrical Isomerism of 3,5-Dicaffeoylquinic Acid on Its Binding Affinity to HIV-Integrase Enzyme: A Molecular Docking Study

A potent plant-derived HIV-1 inhibitor, 3,5-dicaffeoylquinic acid (diCQA), has been shown to undergo isomerisation upon UV exposure where the naturally occurring 3(trans),5(trans)-diCQA isomer gives rise to the 3(cis),5(trans)-diCQA, 3(trans),5(cis)-diCQA, and 3(cis),5(cis)-diCQA isomers. In this st...

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Detalles Bibliográficos
Autores principales: Makola, Mpho M., Dubery, Ian A., Koorsen, Gerrit, Steenkamp, Paul A., Kabanda, Mwadham M., du Preez, Louis L., Madala, Ntakadzeni E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088326/
https://www.ncbi.nlm.nih.gov/pubmed/27829863
http://dx.doi.org/10.1155/2016/4138263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088326/
https://www.ncbi.nlm.nih.gov/pubmed/27829863
http://dx.doi.org/10.1155/2016/4138263

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