Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7

Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5’-diphospho-glucuronosyltransferase 2B7 (UGT2B7) in morphine tolerance-like human normal liver cells, HL-77...

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Detalles Bibliográficos
Autores principales: Yang, Zizhao, Li, Li, Hu, Haihong, Xu, Mingcheng, Gu, Jingkai, Wang, Zaijie Jim, Yu, Lushan, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088436/
https://www.ncbi.nlm.nih.gov/pubmed/27847477
http://dx.doi.org/10.3389/fphar.2016.00404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088436/
https://www.ncbi.nlm.nih.gov/pubmed/27847477
http://dx.doi.org/10.3389/fphar.2016.00404

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