Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells

BACKGROUND: Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in vitro sp...

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Detalles Bibliográficos
Autores principales: Urzúa, Ulises, Ampuero, Sandra, Roby, Katherine F., Owens, Garrison A., Munroe, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088517/
https://www.ncbi.nlm.nih.gov/pubmed/27801298
http://dx.doi.org/10.1186/s12864-016-3068-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088517/
https://www.ncbi.nlm.nih.gov/pubmed/27801298
http://dx.doi.org/10.1186/s12864-016-3068-5

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