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Removal of unwanted variation reveals novel patterns of gene expression linked to sleep homeostasis in murine cortex

BACKGROUND: Why we sleep is still one of the most perplexing mysteries in biology. Strong evidence indicates that sleep is necessary for normal brain function and that sleep need is a tightly regulated process. Surprisingly, molecular mechanisms that determine sleep need are incompletely described....

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Detalles Bibliográficos
Autores principales: Gerstner, Jason R., Koberstein, John N., Watson, Adam J., Zapero, Nikolai, Risso, Davide, Speed, Terence P., Frank, Marcos G., Peixoto, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088519/
https://www.ncbi.nlm.nih.gov/pubmed/27801296
http://dx.doi.org/10.1186/s12864-016-3065-8