Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin, Carol-Anne, Murray, Jennie E., Carroll, Paula, Leitch, Andrea, Mackenzie, Karen J., Halachev, Mihail, Fetit, Ahmed E., Keith, Charlotte, Bicknell, Louise S., Fluteau, Adeline, Gautier, Philippe, Hall, Emma A., Joss, Shelagh, Soares, Gabriela, Silva, João, Bober, Michael B., Duker, Angela, Wise, Carol A., Quigley, Alan J., Phadke, Shubha R., Wood, Andrew J., Vagnarelli, Paola, Jackson, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088565/
https://www.ncbi.nlm.nih.gov/pubmed/27737959
http://dx.doi.org/10.1101/gad.286351.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088565/
https://www.ncbi.nlm.nih.gov/pubmed/27737959
http://dx.doi.org/10.1101/gad.286351.116

Ejemplares similares