Direct chromosome-length haplotyping by single-cell sequencing

Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet methods to directly chart the unique genetic makeup of each parental chromosome are lacking. Here we introduce single-cell DNA template strand sequencing (Strand-seq) as a novel approach to phasing diploid geno...

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Detalles Bibliográficos
Autores principales: Porubský, David, Sanders, Ashley D., van Wietmarschen, Niek, Falconer, Ester, Hills, Mark, Spierings, Diana C.J., Bevova, Marianna R., Guryev, Victor, Lansdorp, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088598/
https://www.ncbi.nlm.nih.gov/pubmed/27646535
http://dx.doi.org/10.1101/gr.209841.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088598/
https://www.ncbi.nlm.nih.gov/pubmed/27646535
http://dx.doi.org/10.1101/gr.209841.116

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