Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

PrimPol is a novel human enzyme that contains both DNA primase and DNA polymerase activities. We present the first structure of human PrimPol in ternary complex with a DNA template-primer and an incoming deoxynucleoside triphosphate (dNTP). The ability of PrimPol to function as a DNA primase stems f...

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Detalles Bibliográficos
Autores principales: Rechkoblit, Olga, Gupta, Yogesh K., Malik, Radhika, Rajashankar, Kanagalaghatta R., Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088642/
https://www.ncbi.nlm.nih.gov/pubmed/27819052
http://dx.doi.org/10.1126/sciadv.1601317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088642/
https://www.ncbi.nlm.nih.gov/pubmed/27819052
http://dx.doi.org/10.1126/sciadv.1601317

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