Cargando…

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies

Nrf2 (nuclear factor [erythroid-derived 2]-like 2; the transcriptional master regulator of the antioxidant stress response) is regulated through interaction with its cytoplasmic inhibitor Keap1 (Kelch-like ECH-associated protein 1), which under basal conditions targets Nrf2 for proteasomal degrad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duleh, Steve, Wang, Xianhong, Komirenko, Allison, Margeta, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088660/ https://www.ncbi.nlm.nih.gov/pubmed/27799074 http://dx.doi.org/10.1186/s40478-016-0384-6

Ejemplares similares

Clinical Utility of LC3 and p62 Immunohistochemistry in Diagnosis of Drug-Induced Autophagic Vacuolar Myopathies: A Case-Control Study
por: Lee, Han S., et al.
Publicado: (2012)

Autophagic vacuolar myopathy is a common feature of CLN3 disease
por: Radke, Josefine, et al.
Publicado: (2018)

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease
por: Nemazanyy, Ivan, et al.
Publicado: (2013)

Skeletal myopathy in Pompe disease: a failure of satellite cell activation?
por: Hiniker, Annie, et al.
Publicado: (2018)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

Educational Case: Mitochondrial Myopathy
por: Lucas, Calixto-Hope G., et al.
Publicado: (2019)

Differential diagnosis of vacuolar myopathies in the NGS era
por: Mair, Dorothea, et al.
Publicado: (2020)

The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury
por: Kumagai, Yoshito, et al.
Publicado: (2013)

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
por: Liu, Shengnan, et al.
Publicado: (2022)

Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
por: Wang, Siliang, et al.
Publicado: (2020)

Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis
por: Orrù, Claudia, et al.
Publicado: (2020)

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway
por: Dialynas, George, et al.
Publicado: (2015)

Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells
por: Jang, Da Eun, et al.
Publicado: (2020)

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer()
por: Kansanen, Emilia, et al.
Publicado: (2013)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism
por: Mitsuishi, Yoichiro, et al.
Publicado: (2012)

Activation of the KEAP1-NRF2-ARE signaling pathway reduces oxidative stress in Hep2 cells
por: Li, Changjiang, et al.
Publicado: (2018)

Mechanism of oxidative stress and Keap-1/Nrf2 signaling pathway in bronchopulmonary dysplasia
por: Ma, Di, et al.
Publicado: (2020)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway
por: Hassanein, Emad H. M., et al.
Publicado: (2020)

Molecular Basis of the KEAP1-NRF2 Signaling Pathway
por: Suzuki, Takafumi, et al.
Publicado: (2023)

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
por: Kidokoro, Kengo, et al.
Publicado: (2023)

Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line
por: Chandiramani, Natasha, et al.
Publicado: (2011)

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
por: Gong, Meiling, et al.
Publicado: (2020)

The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity
por: Lee, Da Hyun, et al.
Publicado: (2017)

Regulation of Keap-1/Nrf2 Signaling Pathway Is Activated by Oxidative Stress in Patients with Premature Rupture of Membranes
por: Zhang, Wenfeng, et al.
Publicado: (2020)

Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways
por: Mizunoe, Yuhei, et al.
Publicado: (2017)

Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains
por: Rahman, Muhammad Arifur, et al.
Publicado: (2021)

The emerging role of the Nrf2–Keap1 signaling pathway in cancer
por: Jaramillo, Melba C., et al.
Publicado: (2013)

The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones
por: de Freitas Silva, Matheus, et al.
Publicado: (2018)

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway
por: Keum, Young-Sam, et al.
Publicado: (2014)

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update
por: Thanas, Christina, et al.
Publicado: (2020)

The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
por: Song, Moon-Young, et al.
Publicado: (2021)

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
por: Adinolfi, Simone, et al.
Publicado: (2023)

Astrocytes increase the activity of synaptic GluN2B NMDA receptors
por: Hahn, Junghyun, et al.
Publicado: (2015)

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012)

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
por: Copple, Ian M., et al.
Publicado: (2010)

Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway
por: You, Longtai, et al.
Publicado: (2021)

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway
por: Dong, Lei, et al.
Publicado: (2023)

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1-Nrf2-ARE Signalling Pathway
por: Wu, Pingping, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h93p0f400i46t04fm7vsvag08g