Cargando…

Effects of flavopiridol on critical regulation pathways of CD133(high)/CD44(high) lung cancer stem cells

BACKGROUND: Flavopiridol a semisynthetic flavone that inhibits cyclin-dependent kinases (CDKs) and has growth-inhibitory activity and induces a blockade of cell-cycle progression at G1-phase and apoptosis in numerous human tumor cell lines and is currently under investigation in phase II clinical tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bozok Cetintas, Vildan, Acikgoz, Eda, Yigitturk, Gurkan, Demir, Kenan, Oktem, Gulperi, Tezcanli Kaymaz, Burçin, Oltulu, Fatih, Aktug, Huseyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2016
Materias:	5700
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089099/ https://www.ncbi.nlm.nih.gov/pubmed/27787370 http://dx.doi.org/10.1097/MD.0000000000005150

Ejemplares similares

Induced growth inhibition, cell cycle arrest and apoptosis in CD133(+)/CD44(+) prostate cancer stem cells by flavopiridol
por: SONER, BURAK CEM, et al.
Publicado: (2014)

Ribosome biogenesis mediates antitumor activity of flavopiridol in CD44(+)/CD24(−) breast cancer stem cells
por: Erol, Ayse, et al.
Publicado: (2017)

Histopathological and molecular analysis in dermis and epidermis of patients with systemic and localized scleroderma
por: Sozeri, Betul, et al.
Publicado: (2014)

Evaluation of the Effects of STZ-Induced Diabetes on In Vitro Fertilization and Early Embryogenesis Processes
por: Aktuğ, Hüseyin, et al.
Publicado: (2013)

The effects of PIKfyve inhibitor YM201636 on claudins and malignancy potential of nonsmall cell cancer cells
por: DOĞAN, Eda, et al.
Publicado: (2021)

Expression profiling of stem cell signaling alters with spheroid formation in CD133(high)/CD44(high) prostate cancer stem cells
por: OKTEM, GULPERI, et al.
Publicado: (2014)

Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer
por: Acikgoz, Ozgur, et al.
Publicado: (2021)

Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells
por: Acikgoz, Eda, et al.
Publicado: (2015)

Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson's Disease in Rats
por: Soner, Burak Cem, et al.
Publicado: (2021)

Prognostic markers compared to CD3+TIL in locally advanced nasopharyngeal carcinoma
por: Al-Rajhi, Nasser, et al.
Publicado: (2021)

In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133(high) to CD133(low) phenotype and reduces the CD133-related invasiveness
por: Brugnoli, Federica, et al.
Publicado: (2013)

Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection
por: Cai, Xiao-Yan, et al.
Publicado: (2016)

Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis
por: Wang, Hong, et al.
Publicado: (2015)

A case report of aggressive course of CD30+ primary cutaneous anaplastic large cell lymphoma
por: Lyu, Wen-Tian, et al.
Publicado: (2021)

Diagnostic Value of Wilms Tumor 1 and CD44 in Langerhans Cell Sarcoma: Case Series of 4 Patients
por: Wang, Chang-song, et al.
Publicado: (2015)

Prognostic value of CD44v9 expression in human cancers: A systematic review and meta-analysis
por: Zeng, Li, et al.
Publicado: (2020)

Usefulness of CD109 expression as a prognostic biomarker in patients with cancer: A systematic review and meta-analysis
por: Koh, Hyun Min, et al.
Publicado: (2021)

Potent interaction of flavopiridol with MRP1
por: Hooijberg, J H, et al.
Publicado: (1999)

Effect of P-glycoprotein on flavopiridol sensitivity
por: Boerner, S A, et al.
Publicado: (2001)

The Pharmacological Implications of Flavopiridol: An Updated Overview
por: Joshi, Hemant, et al.
Publicado: (2023)

Role of CD44(high)/CD133(high) HCT-116 cells in the tumorigenesis of colon cancer
por: Zhou, Jin-Yong, et al.
Publicado: (2016)

Peripheral blood CD45RO(+)T cells is a predictor of the effectiveness of neoadjuvant chemoradiotherapy in locally advanced rectal cancer
por: Zhai, Zhiwei, et al.
Publicado: (2021)

Case-control study on PCSK9 R496W (rs374603772) and D374Y (rs137852912) mutations in Turkish patients with primary dyslipidemia
por: Eroğlu, Zuhal, et al.
Publicado: (2018)

CD44v6: A metastasis-associated biomarker in patients with gastric cancer?: A comprehensive meta-analysis with heterogeneity analysis
por: Lu, Li, et al.
Publicado: (2016)

Prognostic and predictive value of KRAS mutation number in metastatic colorectal cancer
por: Ucar, Gokhan, et al.
Publicado: (2020)

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic markers in patients with extensive-stage small cell lung cancer treated with atezolizumab in combination with chemotherapy
por: Kutlu, Yasin, et al.
Publicado: (2023)

Oxytetracycline have the therapeutic efficiency in CD133(+) HCC population through suppression CD133 expression by decreasing of protein stability of CD133
por: Song, Yeonhwa, et al.
Publicado: (2018)

Detection of programmed death ligand 1 protein and CD8(+) lymphocyte infiltration in plurihormonal pituitary adenomas: A case report and review of the literatures
por: Wang, Pengfei, et al.
Publicado: (2017)

CD56–chimeric antigen receptor T-cell therapy for refractory/recurrent rhabdomyosarcoma: A 3.5-year follow-up case report
por: Jiang, Chiyi, et al.
Publicado: (2019)

Transgenic models are predictive: the herceptin and flavopiridol experience
por: Schmidt, E
Publicado: (2003)

Differential number of CD34+, CD133+ and CD34+/CD133+ cells in peripheral blood of patients with congestive heart failure
por: Fritzenwanger, M, et al.
Publicado: (2009)

Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition
por: Ni, Wenjun, et al.
Publicado: (2010)

T-cell lymphoma with abundant CD20 expression showing a good response to rituximab with gemcitabine, oxiplatin, and L-asparaginase (R-pGEMOX): A case report
por: Shao, Yajuan, et al.
Publicado: (2018)

Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells
por: Friel, Anne M, et al.
Publicado: (2010)

Iterative sorting reveals CD133+ and CD133- melanoma cells as phenotypically distinct populations
por: Grasso, Carole, et al.
Publicado: (2016)

Establishment and validation of a novel risk model based on CD8T cell marker genes to predict prognosis in thyroid cancer by integrated analysis of single-cell and bulk RNA-sequencing
por: Du, Jian, et al.
Publicado: (2023)

PD-L1 – inhibitors in neuroendocrine neoplasia: Results from a real-life study
por: Özdirik, Burcin, et al.
Publicado: (2021)

The prognostic value of tumor/lymph node standardized uptake value max ratio and correlation with hematologic parameters in stage III nonsmall cell lung cancer
por: Açikgoz, Yusuf, et al.
Publicado: (2020)

Circulating tumor cells counts are associated with CD8+ T cell levels in programmed death-ligand 1-negative non-small cell lung cancer patients after radiotherapy: A retrospective study
por: Liu, Qingyun, et al.
Publicado: (2021)

CD133 Expression and Identification of CD133/nestin Positive Cells in Rhabdomyosarcomas and Rhabdomyosarcoma Cell Lines
por: Sana, Jiri, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_53ahp7ppg01ova5iic6qh0ndd4