An affinity-directed protein missile system for targeted proteolysis

The von Hippel–Lindau (VHL) protein serves to recruit the hypoxia-inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome. In this report, we modify VHL to engineer an affinity-directed protein missile (AdPRO...

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Detalles Bibliográficos
Autores principales: Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090066/
https://www.ncbi.nlm.nih.gov/pubmed/27784791
http://dx.doi.org/10.1098/rsob.160255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090066/
https://www.ncbi.nlm.nih.gov/pubmed/27784791
http://dx.doi.org/10.1098/rsob.160255

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