Cargando…

Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier manifestation of neuritic plaques) and fibrillar plaques in Alzheimer’s disease (AD) brain sections, and remarkable specificity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sundaram, G. S. M., Dhavale, Dhruva D., Prior, Julie L., Yan, Ping, Cirrito, John, Rath, Nigam P., Laforest, Richard, Cairns, Nigel J., Lee, Jin-Moo, Kotzbauer, Paul T., Sharma, Vijay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090206/ https://www.ncbi.nlm.nih.gov/pubmed/27805057 http://dx.doi.org/10.1038/srep35636

Ejemplares similares

Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease
por: Sundaram, Guruswami SM, et al.
Publicado: (2015)

Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
por: Sundaram, G.S.M., et al.
Publicado: (2014)

Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
por: Miller, Rebecca L., et al.
Publicado: (2022)

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls
por: Esparza, Thomas J., et al.
Publicado: (2018)

N-(2-Methylphenyl)-1,2-benzoselenazol-3(2H)-one
por: Zhu, Xu, et al.
Publicado: (2013)

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics
por: Yamasaki, Tritia R., et al.
Publicado: (2019)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in (64)Cu PET Imaging for Alzheimer’s Disease
por: Sharma, Anuj K., et al.
Publicado: (2017)

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
por: Barclay, Alexander M., et al.
Publicado: (2023)

Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain
por: Richards, Danielle, et al.
Publicado: (2014)

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Thomas, Riya, et al.
Publicado: (2020)

Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model
por: Cirrito, John R., et al.
Publicado: (2020)

Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
por: Biechele, Gloria, et al.
Publicado: (2022)

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro
por: Hsieh, Chia-Ju, et al.
Publicado: (2018)

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease
por: Querol-Vilaseca, Marta, et al.
Publicado: (2019)

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
por: Luo, Ziyi, et al.
Publicado: (2021)

A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion
por: Sharma, Vijay, et al.
Publicado: (2014)

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
por: Hettinger, Jane C., et al.
Publicado: (2018)

Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity
por: Wildburger, Norelle C., et al.
Publicado: (2018)

Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model
por: Frost, Georgia R., et al.
Publicado: (2020)

Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis
por: Klein, Gregory, et al.
Publicado: (2019)

Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease
por: Chuang, Jia-Ying, et al.
Publicado: (2012)

Migration of blood cells to β-amyloid plaques in Alzheimer’s disease
por: Hohsfield, Lindsay A., et al.
Publicado: (2015)

Quinoline- and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines
por: Lima, Eurico, et al.
Publicado: (2020)

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
por: Pan, Qiuyun, et al.
Publicado: (2023)

Amyloid-Targeting PET Tracer [(18)F]Flutemetamol Accumulates in Atherosclerotic Plaques
por: Hellberg, Sanna, et al.
Publicado: (2019)

Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET
por: Therriault, Joseph, et al.
Publicado: (2023)

Peripheral monocyte–derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer’s disease
por: Yan, Ping, et al.
Publicado: (2022)

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease
por: Fisher, Yair, et al.
Publicado: (2010)

Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease
por: Tong, Hongjuan, et al.
Publicado: (2015)

Amyloid Plaques in Retina for Diagnosis in Alzheimer’s Patients: a Meta-Analysis
por: Jiang, Jiangling, et al.
Publicado: (2016)

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
por: Rahman, M. Mahafuzur, et al.
Publicado: (2021)

The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
por: Drummond, Eleanor, et al.
Publicado: (2022)

Author Correction: Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model
por: Frost, Georgia R., et al.
Publicado: (2020)

Amyloid PET imaging: applications beyond Alzheimer’s disease
por: Catafau, Ana M., et al.
Publicado: (2015)

The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review
por: Brand, Abby L., et al.
Publicado: (2022)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease
por: Roney, Celeste A., et al.
Publicado: (2010)

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
por: Tsai, Andy P., et al.
Publicado: (2022)

Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET
por: Jeon, Seun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rj40vs8lehqj27silomemi790j