Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila

Myotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulatio...

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Detalles Bibliográficos
Autores principales: Cerro-Herreros, Estefania, Fernandez-Costa, Juan M., Sabater-Arcis, María, Llamusi, Beatriz, Artero, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090246/
https://www.ncbi.nlm.nih.gov/pubmed/27805016
http://dx.doi.org/10.1038/srep36230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090246/
https://www.ncbi.nlm.nih.gov/pubmed/27805016
http://dx.doi.org/10.1038/srep36230

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