Natural mutations in IFITM3 modulate post‐translational regulation and toggle antiviral specificity

The interferon‐induced transmembrane (IFITM) proteins protect host cells from diverse virus infections. IFITM proteins also incorporate into HIV‐1 virions and inhibit virus fusion and cell‐to‐cell spread, with IFITM3 showing the greatest potency. Here, we report that amino‐terminal mutants of IFITM3...

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Detalles Bibliográficos
Autores principales: Compton, Alex A, Roy, Nicolas, Porrot, Françoise, Billet, Anne, Casartelli, Nicoletta, Yount, Jacob S, Liang, Chen, Schwartz, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090704/
https://www.ncbi.nlm.nih.gov/pubmed/27601221
http://dx.doi.org/10.15252/embr.201642771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090704/
https://www.ncbi.nlm.nih.gov/pubmed/27601221
http://dx.doi.org/10.15252/embr.201642771

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