Identification of DNA primase inhibitors via a combined fragment-based and virtual screening

The structural differences between bacterial and human primases render the former an excellent target for drug design. Here we describe a technique for selecting small molecule inhibitors of the activity of T7 DNA primase, an ideal model for bacterial primases due to their common structural and func...

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Detalles Bibliográficos
Autores principales: Ilic, Stefan, Akabayov, Sabine R., Arthanari, Haribabu, Wagner, Gerhard, Richardson, Charles C., Akabayov, Barak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090872/
https://www.ncbi.nlm.nih.gov/pubmed/27805033
http://dx.doi.org/10.1038/srep36322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090872/
https://www.ncbi.nlm.nih.gov/pubmed/27805033
http://dx.doi.org/10.1038/srep36322

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