Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine

Accumulation of phosphatidylserine in the inner leaflet of the plasma membrane is a hallmark of eukaryotes. Sublethal levels of staurosporine and related compounds deplete phosphatidylserine from the plasma membrane and abrogate K-Ras signaling. Here, we report that low-dose staurosporine and relate...

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Detalles Bibliográficos
Autores principales: Maekawa, Masashi, Lee, Minhyoung, Wei, Kuiru, Ridgway, Neale D., Fairn, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090970/
https://www.ncbi.nlm.nih.gov/pubmed/27805006
http://dx.doi.org/10.1038/srep35762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090970/
https://www.ncbi.nlm.nih.gov/pubmed/27805006
http://dx.doi.org/10.1038/srep35762

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