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Using HHsearch to tackle proteins of unknown function: A pilot study with PH domains

Advances in membrane cell biology are hampered by the relatively high proportion of proteins with no known function. Such proteins are largely or entirely devoid of structurally significant domain annotations. Structural bioinformaticians have developed profile‐profile tools such as HHsearch (online...

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Detalles Bibliográficos
Autores principales: Fidler, David R., Murphy, Sarah E., Courtis, Katherine, Antonoudiou, Pantelis, El‐Tohamy, Rana, Ient, Jonathan, Levine, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091641/
https://www.ncbi.nlm.nih.gov/pubmed/27601190
http://dx.doi.org/10.1111/tra.12432