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Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis

Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microsca...

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Detalles Bibliográficos
Autores principales: Ning, Chengyun, Yu, Peng, Zhu, Ye, Yao, Mengyu, Zhu, Xiaojing, Wang, Xiaolan, Lin, Zefeng, Li, Weiping, Wang, Shuangying, Tan, Guoxin, Zhang, Yu, Wang, Yingjun, Mao, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091659/
https://www.ncbi.nlm.nih.gov/pubmed/27818718
http://dx.doi.org/10.1038/am.2016.9
Descripción
Sumario:Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO(2) zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase–rutile-phase transition in selective areas using laser irradiation on the implants. The in vitro and in vivo studies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF.