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Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis

Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microsca...

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Autores principales: Ning, Chengyun, Yu, Peng, Zhu, Ye, Yao, Mengyu, Zhu, Xiaojing, Wang, Xiaolan, Lin, Zefeng, Li, Weiping, Wang, Shuangying, Tan, Guoxin, Zhang, Yu, Wang, Yingjun, Mao, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091659/
https://www.ncbi.nlm.nih.gov/pubmed/27818718
http://dx.doi.org/10.1038/am.2016.9
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author Ning, Chengyun
Yu, Peng
Zhu, Ye
Yao, Mengyu
Zhu, Xiaojing
Wang, Xiaolan
Lin, Zefeng
Li, Weiping
Wang, Shuangying
Tan, Guoxin
Zhang, Yu
Wang, Yingjun
Mao, Chuanbin
author_facet Ning, Chengyun
Yu, Peng
Zhu, Ye
Yao, Mengyu
Zhu, Xiaojing
Wang, Xiaolan
Lin, Zefeng
Li, Weiping
Wang, Shuangying
Tan, Guoxin
Zhang, Yu
Wang, Yingjun
Mao, Chuanbin
author_sort Ning, Chengyun
collection PubMed
description Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO(2) zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase–rutile-phase transition in selective areas using laser irradiation on the implants. The in vitro and in vivo studies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF.
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spelling pubmed-50916592017-03-04 Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis Ning, Chengyun Yu, Peng Zhu, Ye Yao, Mengyu Zhu, Xiaojing Wang, Xiaolan Lin, Zefeng Li, Weiping Wang, Shuangying Tan, Guoxin Zhang, Yu Wang, Yingjun Mao, Chuanbin NPG Asia Mater Article Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO(2) zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase–rutile-phase transition in selective areas using laser irradiation on the implants. The in vitro and in vivo studies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF. 2016-03-04 2016 /pmc/articles/PMC5091659/ /pubmed/27818718 http://dx.doi.org/10.1038/am.2016.9 Text en http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ning, Chengyun
Yu, Peng
Zhu, Ye
Yao, Mengyu
Zhu, Xiaojing
Wang, Xiaolan
Lin, Zefeng
Li, Weiping
Wang, Shuangying
Tan, Guoxin
Zhang, Yu
Wang, Yingjun
Mao, Chuanbin
Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title_full Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title_fullStr Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title_full_unstemmed Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title_short Built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
title_sort built-in microscale electrostatic fields induced by anatase–rutile-phase transition in selective areas promote osteogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091659/
https://www.ncbi.nlm.nih.gov/pubmed/27818718
http://dx.doi.org/10.1038/am.2016.9
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