RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the recept...

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Detalles Bibliográficos
Autores principales: McKelvey, Alison C, Lear, Travis B, Dunn, Sarah R, Evankovich, John, Londino, James D, Bednash, Joseph S, Zhang, Yingze, McVerry, Bryan J, Liu, Yuan, Chen, Bill B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092053/
https://www.ncbi.nlm.nih.gov/pubmed/27805901
http://dx.doi.org/10.7554/eLife.18496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092053/
https://www.ncbi.nlm.nih.gov/pubmed/27805901
http://dx.doi.org/10.7554/eLife.18496

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