The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cycle arrest after ionizing radiation and diminished...

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Detalles Bibliográficos
Autores principales: Karlseder, Jan, Hoke, Kristina, Mirzoeva, Olga K, Bakkenist, Christopher, Kastan, Michael B, Petrini, John H. J, de Lange, Titia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://www.ncbi.nlm.nih.gov/pubmed/15314656
http://dx.doi.org/10.1371/journal.pbio.0020240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://www.ncbi.nlm.nih.gov/pubmed/15314656
http://dx.doi.org/10.1371/journal.pbio.0020240

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