TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB c-REL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer

The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanC...

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Detalles Bibliográficos
Autores principales: Si, Han, Lu, Hai, Yang, Xinping, Mattox, Austin, Jang, Minyoung, Bian, Yansong, Sano, Eleanor, Viadiu, Hector, Yan, Bin, Yau, Christina, Ng, Sam, Lee, Steven K., Romano, Rose-Anne, Davis, Sean, Walker, Robert L., Xiao, Wenming, Sun, Hongwei, Wei, Lai, Sinha, Satrajit, Benz, Christopher C, Stuart, Joshua M., Meltzer, Paul S., Van Waes, Carter, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093089/
https://www.ncbi.nlm.nih.gov/pubmed/27132513
http://dx.doi.org/10.1038/onc.2016.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093089/
https://www.ncbi.nlm.nih.gov/pubmed/27132513
http://dx.doi.org/10.1038/onc.2016.112

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