Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals

PURPOSE: Determine the pharmacokinetics of insulin peglispro (BIL) in 5/6-nephrectomized rats and study the absorption in lymph duct cannulated (LDC) sheep. METHODS: BIL is insulin lispro modified with 20-kDa linear PEG at lysine B28 increasing the hydrodynamic size to 4-fold larger than insulin lis...

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Detalles Bibliográficos
Autores principales: Knadler, Mary Pat, Nguyen, Tri-Hung, Campanale, Kristina, De Veer, Michael J., Beals, John M., Li, Shun, Hansen, Ryan, Siesky, Angela, Michael, M. Dodson, Porter, Christopher J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093203/
https://www.ncbi.nlm.nih.gov/pubmed/27528391
http://dx.doi.org/10.1007/s11095-016-2014-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093203/
https://www.ncbi.nlm.nih.gov/pubmed/27528391
http://dx.doi.org/10.1007/s11095-016-2014-1

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