Gene Expression Profile of Colon Mucosa after Cytotoxic Insult in wt and Apc-Mutated Pirc Rats: Possible Relation to Resistance to Apoptosis during Carcinogenesis

Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis. To understand this phenomenon, we analyzed the expression of genotoxic stress-related genes Mgmt, Gsta1, and Gstp1 in the colon of wt and Pirc rats in basal con...

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Detalles Bibliográficos
Autores principales: Femia, Angelo Pietro, Luceri, Cristina, Lodovici, Maura, Crucitta, Stefania, Caderni, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093255/
https://www.ncbi.nlm.nih.gov/pubmed/27840820
http://dx.doi.org/10.1155/2016/1310342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093255/
https://www.ncbi.nlm.nih.gov/pubmed/27840820
http://dx.doi.org/10.1155/2016/1310342

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