Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy

Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin’s lymphoma (NHL). An alternative to current antibody-based therapies is the...

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Detalles Bibliográficos
Autores principales: Madge, Paul D., Maggioni, Andrea, Pascolutti, Mauro, Amin, Moein, Waespy, Mario, Bellette, Bernadette, Thomson, Robin J., Kelm, Sørge, von Itzstein, Mark, Haselhorst, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093622/
https://www.ncbi.nlm.nih.gov/pubmed/27808110
http://dx.doi.org/10.1038/srep36012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093622/
https://www.ncbi.nlm.nih.gov/pubmed/27808110
http://dx.doi.org/10.1038/srep36012

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